Input and runtime details for job 8167883 (precomputed example)

Input Parameters

	Protein/Peptide FASTA		[.fa]
	Protein UniProt IDs		[.fa]
	SH2 Domains		CRKL, CRK, GRB2

Filters

	Phosphotyrosine (pY) (needs UniProt IDs)		yes
	Cellular localization (needs UniProt IDs)		yes

Job ID 8167883 (server version 4.2.2)

	Job Submitted & Queued		@ Fri Jul 22 10:48:34 CEST 2016
	SH2PepInt Started		@ Fri Jul 22 10:48:42 CEST 2016
	SH2PepInt Finished & Post-Processing		@ Fri Jul 22 10:49:36 CEST 2016
	Job Completed		@ Fri Jul 22 10:49:39 CEST 2016

DIRECT ACCESS: http://modpepint.informatik.uni-freiburg.de/RetrieveResults.jsp?jobID=8167883&toolName=SH2PepInt ( 30 days expiry )

Description of the job

This is an example for the interaction prediction of human SH2 domains from GRB2, CRK and CRKL proteins with the target proteins ERBB1, ERBB2 and ERBB3.

Output download complete results [zip]

[Download] the following interaction table

Sort by selecting a column name.

Sequence ID	Position	Sequence	Domain
sp\|P00533\|EGFR_HUMAN	pY112	NMYYENS	CRKL, CRK
sp\|P00533\|EGFR_HUMAN	pY585	AHYIDGP	GRB2
sp\|P00533\|EGFR_HUMAN	pY944	DVYMIMV	CRK
sp\|P00533\|EGFR_HUMAN	pY998	NFYRALM	CRK
sp\|P00533\|EGFR_HUMAN	pY1016	DEYLIPQ	CRKL, CRK
sp\|P00533\|EGFR_HUMAN	pY1092	PEYINQS	GRB2
sp\|P00533\|EGFR_HUMAN	pY1110	PVYHNQP	GRB2
sp\|P00533\|EGFR_HUMAN	pY1125	PHYQDPH	CRKL, CRK
sp\|P00533\|EGFR_HUMAN	pY1138	PEYLNTV	GRB2
sp\|P00533\|EGFR_HUMAN	pY1197	AEYLRVA	CRKL, CRK
P04626	pY1005	TFYRSLL	CRK
P04626	pY1023	EEYLVPQ	CRKL, CRK
P04626	pY1127	DGYVAPL	CRKL, CRK
P04626	pY1139	PEYVNQP	GRB2
P04626	pY1222	LYYWDQD	CRKL

Job resubmission

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When using SH2PepInt please cite :

Kousik Kundu, Martin Mann, Fabrizio Costa, and Rolf Backofen
MoDPepInt: An interactive webserver for prediction of modular domain-peptide interactions
Bioinformatics, 2014, in press.
Kousik Kundu, Fabrizio Costa, Michael Huber, Michael Reth, and Rolf Backofen
Semi-Supervised Prediction of SH2-Peptide Interactions from Imbalanced High-Throughput Data
PLoS One, 8(5), pp. e62732, 2013.

Results are computed with SH2PepInt version 1.0.0

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