This web server provides online access to a series of tools
developed by the Freiburg Bioinformatics Group.
To start using it, please select from the listings below,
or use the menu on the left. If you prefer doing a
local installation on your machine, please visit our
If you use our tools for research or education, please
the corresponding articles from the
MoDPepInt (Modular Domain Peptide Interaction)
is a simple and interactive webserver, which
comprises three different tools, i.e. SH2PepInt, SH3PepInt and PDZPepInt,
for predicting the binding partners of three
different modular protein domains,
i.e. SH2, SH3 and PDZ domains, respectively.
SH2PepInt has been developed to predict binding partners to more than 50 human
SH2 domains. Depending on
the user requirement it uses PhosphoSitePlus and Gene Ontology
databases for predicting highly reliable SH2-peptide interactions.
SH3PepInt is a fast and sophisticated graph kernel based tool
to predict SH3-peptide interactions. About 70 built-in models are
available for SH3-peptide predictions. It does not need any pre-alignment
of the peptides and uses Gene
Ontology database for getting more reliable interactions.
PDZPepInt is a cluster based prediction tool to predict binding
peptides of PDZ domains in human, mouse, fly and worm. About 40
built-in models that cover more than 220 PDZ domains across the species are
available. Gene Ontology
database can be used for getting reliable interactions. Additionally,
it will also consider the C-terminal peptides that are intrinsically
unstructured for getting high confidence interactions.
MoDPepInt is a meta-tool that runs interaction screens for
all domains-specific tools listed here. It might be used as a
starting point if no target domain information is known.