[Download]
the SH2 interaction table
Input and runtime details for job 4305227 (precomputed example)
Job ID 4305227 (server version 4.2.2)
 | Job Submitted & Queued | @ Fri Jul 22 10:50:21 CEST 2016 | |
| MetaServer Started | @ Fri Jul 22 10:50:27 CEST 2016 | |
| MetaServer Finished & Post-Processing | @ Fri Jul 22 11:01:20 CEST 2016 | |
| Job Completed | @ Fri Jul 22 11:01:22 CEST 2016 |
DIRECT ACCESS: http://modpepint.informatik.uni-freiburg.de/RetrieveResults.jsp?jobID=4305227&toolName=MetaServer ( 30 days expiry )
Description of the job
This is an example for the interaction prediction of human SH2, SH3 and PDZ domains with two sample target proteins.
Output download complete results [zip]
SH2-peptide interactions (top 5 per domain)
Sort by selecting a column name.
| Sequence ID | Position | Sequence | Domain |
|---|---|---|---|
| Sample-1 | Y24 | KRYAWKR | EAT2, FGR, HCK |
| Sample-1 | Y48 | EYYKNDH | BMX, GRAP2, GRB2, MIST, SOCS5, TEC, VAV1 |
| Sample-1 | Y83 | NSYIFDI | BLK, GRB14 |
| Sample-1 | Y95 | IFYLVAD | BMX, E109111, SH2D2A |
| Sample-1 | Y183 | QDYLLLI | BRDG1, SH2B, SHC1, SHC3, SRC, TENS1 |
| Sample-1 | Y242 | MIYDSPP | ABL1, FRK, LCP2, NCK1, NCK2 |
| Sample-1 | Y259 | SLYNLPR | ABL1, ABL2, BLK, CRKL, CRK, CTEN, NCK2, SH2D1A, SH2D3C |
| Sample-1 | Y285 | ELYVFNT | APS, BCAR3, BTK, CRK, CTEN, E105251, E109111, EAT2, GRB10, GRB14, SH2B, SH2D1A, TENC1, TNS, TXK, YES1 |
| Sample-1 | Y307 | ISYDIPP | ABL1, ABL2, APS, BMX, BRDG1, BTK, CRKL, CRK, CTEN, E105251, E109111, FGR, FRK, GRB14, HCK, INPPL1, ITK, LCK, LCP2, LYN, MATK, MIST, NCK1, NCK2, PTK6, SH2B, SH2D1A, SH2D2A, SH2D3C, SHC3, SOCS5, SRC, TEC, TENC1, TENS1, TNS, TXK, VAV1, VAV2, YES1 |
| Sample-1 | Y317 | NTYQIPR | ABL1, BCAR3, BLK, CRKL, CRK, E109111, FGR, GRB10, HCK, LCK, LCP2, LYN, MATK, MIST, SH2D3C, SOCS2, SOCS5, SRC, VAV1 |
| Sample-1 | Y373 | SSYCIPT | ABL2, CTEN, E185634, INPPL1, MATK, VAV1, VAV2 |
| Sample-1 | Y406 | DCYDIPR | ABL1, ABL2, BCAR3, BLK, BRDG1, BTK, CRKL, CRK, CTEN, E105251, E185634, FES, FRK, GRB10, GRB14, HCK, INPPL1, ITK, LCK, LCP2, MIST, NCK1, NCK2, PTK6, SHC1, SHC3, SRC, TEC, TENC1, TENS1, TNS, TXK, VAV1 |
| Sample-1 | Y447 | ENYVPMN | SOCS2 |
| Sample-1 | Y472 | ANYVPMT | LYN, NCK1 |
| Sample-1 | Y589 | ENYVPMN | SOCS2 |
| Sample-1 | Y627 | VEYLDLD | APS, FRK, SH2B |
| Sample-1 | Y659 | VDYVVVD | EAT2, MATK, PTK6, SHC1 |
| Sample-2 | Y8 | GLYGLGE | E185634, EAT2, FGR, INPPL1, SHC3 |
| Sample-2 | Y60 | DGYGSLP | APS, E105251, FES, FRK, GRB10, GRB14, LCP2, MIST, SH2B, SHC1, SHC3, SOCS2, SOCS5 |
| Sample-2 | Y132 | LRYFDPL | ABL2, APS, BMX, BRDG1, BTK, CRKL, E105251, GRB10, GRB2, HCK, LCK, LYN, PTK6, SH2D2A, SH2D3C, TEC, TENC1, TENS1, TNS, TXK, VAV2, YES1 |
| Sample-2 | Y155 | LYYYQSG | BCAR3, SH2D1A |
| Sample-2 | Y156 | YYYQSGG | BCAR3, EAT2, SH2D1A |
| Sample-2 | Y180 | KFYELGD | E185634, FER, FES, NCK1, NCK2, SH2D2A, SOCS5, YES1 |
| Sample-2 | Y219 | FEYPESS | ITK |
| Sample-2 | Y323 | IPYFITL | BLK, BMX, BRDG1, BTK, E109111, E185634, FGR, INPPL1, LCK, LYN, MATK, PTK6, SH2D2A, SH2D3C, SHC1, SOCS2, SRC, TEC, TENC1, TENS1, TNS, TXK, VAV2, YES1 |
| Sample-2 | Y507 | CPYLPGT | VAV2 |
If you are interested in a deeper screen for this domain, please
refer to the dedicated tool. It offers further filtering options
and will provide the complete interaction list. You can directly
feed your input with the following button.
SH3-peptide interactions (top 5 per domain)
Sort by selecting a column name.
| Sequence ID | Position | Sequence | Domain |
|---|---|---|---|
| Sample-1 | 341-355 | PPPRPPKPHPAHDRS | AMPHIPHYSIN_I, ARGBP2a-1, DDEF2, ENDOPHILIN1, ENDOPHILIN2, ENDOPHILIN3, FGR, GRAP2-2, PIK3R1, SH3PX3, SNX9, TUBA-6 |
| Sample-1 | 491-505 | PPAHMGFRSSPKTPP | CIN85-3, RASGAP, STAM1 |
| Sample-1 | 501-515 | PKTPPRRPVPVADCE | AMPHIPHYSIN_I, ARGBP2a-1, ENDOPHILIN1, FGR, INTERSECTIN1-3, OSTF1, PAC3, SH3PX3, TUBA-3, TUBA-6 |
| Sample-2 | 501-515 | HVTSCPYLPGTLGQH | EPS8L2, IRSP53 |
[Download]
the SH3 interaction table
If you are interested in a deeper screen for this domain, please
refer to the dedicated tool. It offers further filtering options
and will provide the complete interaction list. You can directly
feed your input with the following button.
PDZ-peptide interactions (top 5 per domain)
Sort by selecting a column name.
| Sequence ID | Position | Sequence | Domain |
|---|---|---|---|
| Sample-1 | 690-694 | AKSVK | GIPC2_Mouse, GIPC1_Mouse, PATJ-2_Drome, MPDZ-3_Mouse, GIPC2_Human, GIPC3_Human, GIPC3_Mouse, INADL-3_Human, INADL-3_Mouse, MPDZ-3_Human, GIPC1_Human |
[Download]
the PDZ interaction table
If you are interested in a deeper screen for this domain, please
refer to the dedicated tool. It offers further filtering options
and will provide the complete interaction list. You can directly
feed your input with the following button.
Job resubmission
Use the following button if you want to resubmit the job with
altered input or parameterization:
usability assessment
When using MetaServer please cite :
- Kousik Kundu, Martin Mann, Fabrizio Costa, and Rolf Backofen
MoDPepInt: An interactive webserver for prediction of modular domain-peptide interactions
Bioinformatics, 2014, in press. - Kousik Kundu, Fabrizio Costa, Michael Huber, Michael Reth, and Rolf Backofen
Semi-Supervised Prediction of SH2-Peptide Interactions from Imbalanced High-Throughput Data
PLoS One, 8(5), pp. e62732, 2013. - Kousik Kundu, Fabrizio Costa, and Rolf Backofen
A graph kernel approach for alignment-free domain-peptide interaction prediction with an application to human SH3 domains
Bioinformatics, 29(13), pp. i335-i343, 2013. - Kousik Kundu and Rolf Backofen
Cluster based prediction of PDZ-peptide interactions
BMC Genomics, 15 Suppl 1 pp. S5, 2014.
Results are computed with MetaServer version 1.0.0
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